DHX16

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. {ECO:0000269|PubMed:20423332, ECO:0000269|PubMed:20841358, ECO:0000269|PubMed:25296192}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 115/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	1/28
bone	5/26
breast	5/33
central nervous system	6/56
cervix	0/4
colorectal	5/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	4/20
lung	14/75
lymphocyte	2/16
ovary	4/26
pancreas	4/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	3/29
uterus	1/5

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-1.77
RK-33 8μM R08 exp518	1.89

3-5 RNA helicase activity
U2-type precatalytic spliceosome
RNA helicase activity
spliceosomal complex
ATPase activity
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
ATP binding
RNA metabolic process
gene expression