DHX8 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX8
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1659|1659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14562|Q14562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600396|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. {ECO:0000269|PubMed:8608946}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|OB NTP bind|
|HA2|
|S1|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal complex disassembly|
|ribonucleoprotein complex disassembly|
|3-5 RNA helicase activity|
|U2-type catalytic step 2 spliceosome|
|RNA helicase activity|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|nuclear body|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|cellular component disassembly|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|identical protein binding|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.33|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.23|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.21|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.2|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.01|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.83|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.81|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.81|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.76|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.75|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.74|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.7|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.7|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.72|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.84|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.89|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.93|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.94|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.97|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.446|
|[[:human genes:r:rrm1|RRM1]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX8 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>