DHX8

Entrez Summary: N/A
UniProt Summary: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. {ECO:0000269|PubMed:8608946}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-2.75
Actinomycin-D 0.001μM R00 exp3	-2.33
GSK626616 14μM R08 exp485	-2.23
5-Fluorouracil 20μM R00 exp2	-2.21
GSK-J4 1-1.25μM to day4 R07 exp363	-2.2
ZLN024 50μM R08 exp538	-2.01
Pyrazinamide 100μM R08 exp516	-1.85
Oligomycin-A 20μM R00 exp26	-1.83
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.81
Pimelic-diphenylamide-106 5μM R00 exp28	-1.81
Doxorubicin 0.02μM R08 exp478	-1.76
Nocodazole 0.2μM R00 exp24	-1.75
SB743921 0.001μM R05 exp244	-1.74
proTAME 5μM R04 exp187	-1.7
Ibrutinib 10μM R08 exp442	1.7
Cannabidiol 20μM R08 exp466	1.72
BI-2536 0.001μM R01 exp41	1.84
L-74142 5μM R03 exp131	1.89
Olaparib 4μM R08 exp512	1.93
Arsenic trioxide 60μM R08 exp449	1.94
Momordin-Ic 10μM R08 exp506	1.97
Pyronaridine 1μM R06 exp295	2.24

Global Fraction of Cell Lines Where Essential: 735/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
PRIM1	0.446
RRM1	0.418

spliceosomal complex disassembly
ribonucleoprotein complex disassembly
3-5 RNA helicase activity
U2-type catalytic step 2 spliceosome
RNA helicase activity
catalytic step 2 spliceosome
spliceosomal complex
protein-containing complex disassembly
ribonucleoprotein complex subunit organization
nuclear body
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
cellular component disassembly
mRNA processing
mRNA metabolic process
RNA processing
identical protein binding
RNA binding
ATP binding
RNA metabolic process
protein-containing complex subunit organization
gene expression