DIO2

Entrez Summary: N/A
UniProt Summary: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thyroid hormone catabolic process
thyroxine 5-deiodinase activity
translational readthrough
selenocysteine incorporation
selenium binding
thyroid hormone generation
phenol-containing compound catabolic process
hormone catabolic process
thyroid hormone metabolic process
cellular modified amino acid catabolic process
hormone biosynthetic process
organic hydroxy compound catabolic process
phenol-containing compound metabolic process
positive regulation of cold-induced thermogenesis
translational elongation
regulation of cold-induced thermogenesis
cellular modified amino acid metabolic process
hormone metabolic process
ubiquitin protein ligase binding
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
aromatic compound catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
regulation of hormone levels
cellular amide metabolic process
oxidation-reduction process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
positive regulation of multicellular organismal process
macromolecule biosynthetic process
organic substance catabolic process
cellular catabolic process