DKK3 [The Human Chemical-Genetic Interaction Map Project]

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======= DKK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DKK3
  * **<color #00a2e8>Official Name</color>**: dickkopf WNT signaling pathway inhibitor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27122|27122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBP4|Q9UBP4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DKK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DKK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605416|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dickkopf N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of anti-Mullerian hormone signaling pathway|
|regulation of anti-Mullerian hormone signaling pathway|
|negative regulation of aldosterone metabolic process|
|negative regulation of cortisol biosynthetic process|
|negative regulation of aldosterone biosynthetic process|
|negative regulation of steroid hormone biosynthetic process|
|negative regulation of glucocorticoid biosynthetic process|
|negative regulation of glucocorticoid metabolic process|
|regulation of cortisol biosynthetic process|
|regulation of aldosterone biosynthetic process|
|regulation of aldosterone metabolic process|
|regulation of glucocorticoid biosynthetic process|
|regulation of glucocorticoid metabolic process|
|negative regulation of hormone biosynthetic process|
|regulation of steroid hormone biosynthetic process|
|negative regulation of hormone metabolic process|
|negative regulation of alcohol biosynthetic process|
|co-receptor binding|
|regulation of ketone biosynthetic process|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|adrenal gland development|
|regulation of hormone biosynthetic process|
|receptor antagonist activity|
|regulation of hormone metabolic process|
|negative regulation of lipid biosynthetic process|
|negative regulation of signaling receptor activity|
|regulation of alcohol biosynthetic process|
|negative regulation of lipid metabolic process|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of steroid metabolic process|
|regulation of cellular response to transforming growth factor beta stimulus|
|endocrine system development|
|regulation of cellular ketone metabolic process|
|regulation of signaling receptor activity|
|negative regulation of canonical Wnt signaling pathway|
|regulation of lipid biosynthetic process|
|negative regulation of Wnt signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|regulation of lipid metabolic process|
|gland development|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of hormone levels|
|cell-cell signaling|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DKK3 Expression in NALM6 Cells: -0.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>