DKK3

Gene Information

Official Symbol: DKK3
Official Name: dickkopf WNT signaling pathway inhibitor 3
Aliases and Previous Symbols: N/A
Entrez ID: 27122
UniProt: Q9UBP4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7880
Expression level (log2 read counts): -0.97

Expression Distribution

negative regulation of anti-Mullerian hormone signaling pathway
regulation of anti-Mullerian hormone signaling pathway
negative regulation of aldosterone metabolic process
negative regulation of cortisol biosynthetic process
negative regulation of aldosterone biosynthetic process
negative regulation of steroid hormone biosynthetic process
negative regulation of glucocorticoid biosynthetic process
negative regulation of glucocorticoid metabolic process
regulation of cortisol biosynthetic process
regulation of aldosterone biosynthetic process
regulation of aldosterone metabolic process
regulation of glucocorticoid biosynthetic process
regulation of glucocorticoid metabolic process
negative regulation of hormone biosynthetic process
regulation of steroid hormone biosynthetic process
negative regulation of hormone metabolic process
negative regulation of alcohol biosynthetic process
co-receptor binding
regulation of ketone biosynthetic process
negative regulation of steroid biosynthetic process
negative regulation of steroid metabolic process
adrenal gland development
regulation of hormone biosynthetic process
receptor antagonist activity
regulation of hormone metabolic process
negative regulation of lipid biosynthetic process
negative regulation of signaling receptor activity
regulation of alcohol biosynthetic process
negative regulation of lipid metabolic process
regulation of steroid biosynthetic process
negative regulation of small molecule metabolic process
regulation of transforming growth factor beta receptor signaling pathway
regulation of steroid metabolic process
regulation of cellular response to transforming growth factor beta stimulus
endocrine system development
regulation of cellular ketone metabolic process
regulation of signaling receptor activity
negative regulation of canonical Wnt signaling pathway
regulation of lipid biosynthetic process
negative regulation of Wnt signaling pathway