DLG1
Gene Information
- Official Symbol: DLG1
- Official Name: discs large MAGUK scaffold protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1739
- UniProt: Q12959
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| PDZ |
| Guanylate kin |
| PDZ assoc |
| L27 1 |
| SH3 1 |
| MAGUK N PEST |
GO Terms
| regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| structural constituent of postsynaptic density |
| cortical microtubule organization |
| L27 domain binding |
| regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| maintenance of postsynaptic density structure |
| lateral loop |
| MPP7-DLG1-LIN7 complex |
| regulation of membrane repolarization during cardiac muscle cell action potential |
| maintenance of postsynaptic specialization structure |
| negative regulation of p38MAPK cascade |
| myelin sheath abaxonal region |
| hard palate development |
| astral microtubule organization |
| regulation of potassium ion export across plasma membrane |
| regulation of membrane repolarization during action potential |
| regulation of potassium ion import |
| establishment of centrosome localization |
| guanylate kinase activity |
| GDP metabolic process |
| peristalsis |
| cell projection membrane |
| T cell cytokine production |
| protein localization to postsynaptic specialization membrane |
| neurotransmitter receptor localization to postsynaptic specialization membrane |
| mitogen-activated protein kinase kinase binding |
| immunological synapse formation |
| ionotropic glutamate receptor complex |
| maintenance of synapse structure |
| node of Ranvier |
| GMP metabolic process |
| regulation of ventricular cardiac muscle cell action potential |
| smooth muscle tissue development |
| postsynaptic density organization |
| amyloid precursor protein metabolic process |
| phasic smooth muscle contraction |
| postsynaptic specialization organization |
| membrane raft organization |
| cytokine production involved in immune response |
| regulation of ventricular cardiac muscle cell membrane repolarization |
| postsynaptic density membrane |
| endothelial cell proliferation |
| cellular protein-containing complex localization |
| secondary palate development |
| regulation of protein localization to synapse |
| synaptic membrane |
| regulation of cardiac muscle cell membrane repolarization |
| regulation of cardiac muscle cell action potential |
| centrosome localization |
| microtubule organizing center localization |
| ionotropic glutamate receptor binding |
| protein localization to postsynaptic membrane |
| regulation of membrane repolarization |
| bicellular tight junction assembly |
| regulation of NMDA receptor activity |
| immunological synapse |
| purine ribonucleoside monophosphate metabolic process |
| tight junction assembly |
| regulation of cardiac muscle cell contraction |
| purine nucleoside monophosphate metabolic process |
| tight junction organization |
| potassium channel regulator activity |
| guanosine-containing compound metabolic process |
| regulation of p38MAPK cascade |
| receptor localization to synapse |
| phosphoprotein phosphatase activity |
| T cell mediated immunity |
| regulation of actin filament-based movement |
| regulation of myelination |
| cortical actin cytoskeleton organization |
| branching involved in ureteric bud morphogenesis |
| positive regulation of potassium ion transport |
| negative regulation of stress-activated MAPK cascade |
| apical junction assembly |
| negative regulation of stress-activated protein kinase signaling cascade |
| intercalated disc |
| establishment or maintenance of epithelial cell apical/basal polarity |
| negative regulation of protein kinase B signaling |
| cellular component maintenance |
| receptor clustering |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| cortical cytoskeleton organization |
| molecular adaptor activity |
| establishment or maintenance of apical/basal cell polarity |
| phosphatase binding |
| establishment or maintenance of bipolar cell polarity |
| regulation of action potential |
| ribonucleoside monophosphate metabolic process |
| smooth muscle contraction |
| cytoplasmic microtubule organization |
| ureteric bud morphogenesis |
| cytoplasmic side of plasma membrane |
| mesonephric tubule morphogenesis |
| positive regulation of protein localization to plasma membrane |
| regulation of potassium ion transmembrane transporter activity |
| lateral plasma membrane |
| negative regulation of T cell proliferation |
| purine ribonucleoside metabolic process |
| purine nucleoside diphosphate metabolic process |
| positive regulation of protein localization to cell periphery |
| purine ribonucleoside diphosphate metabolic process |
| regulation of sodium ion transmembrane transport |
| protein localization to synapse |
| purine nucleoside metabolic process |
| nephron tubule morphogenesis |
| ribonucleoside diphosphate metabolic process |
| regulation of glutamate receptor signaling pathway |
| negative regulation of ERK1 and ERK2 cascade |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| cell-cell recognition |
| nucleoside monophosphate metabolic process |
| negative regulation of lymphocyte proliferation |
| regulation of neurotransmitter receptor activity |
| negative regulation of mononuclear cell proliferation |
| ribonucleoside metabolic process |
| cytoskeletal protein binding |
| regulation of cardiac muscle contraction |
| nephron tubule development |
| lens development in camera-type eye |
| neuromuscular junction |
| negative regulation of leukocyte proliferation |
| renal tubule development |
| regulation of potassium ion transmembrane transport |
| nucleoside diphosphate metabolic process |
| localization within membrane |
| kidney morphogenesis |
| ureteric bud development |
| epithelial cell proliferation |
| mesonephric tubule development |
| regulation of sodium ion transport |
| mesonephric epithelium development |
| basement membrane |
| postsynapse organization |
| roof of mouth development |
| mesonephros development |
| regulation of striated muscle contraction |
| positive regulation of actin filament polymerization |
| embryonic skeletal system morphogenesis |
| regulation of protein localization to plasma membrane |
| regulation of potassium ion transport |
| nephron epithelium development |
| sarcolemma |
| cell-cell junction assembly |
| nucleoside metabolic process |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of T cell activation |
| regulation of protein localization to cell periphery |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of protein localization to membrane |
| bicellular tight junction |
| negative regulation of epithelial cell proliferation |
| nephron development |
| ion channel binding |
| embryonic skeletal system development |
| positive regulation of protein polymerization |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| glycosyl compound metabolic process |
| cell-cell junction organization |
| negative regulation of lymphocyte activation |
| cytokine production |
| regulation of cell shape |
| mitotic cell cycle checkpoint |
| spindle organization |
| regulation of T cell proliferation |
| morphogenesis of a branching epithelium |
| regulation of muscle contraction |
| regulation of actin filament polymerization |
| negative regulation of MAPK cascade |
| morphogenesis of a branching structure |
| cell junction assembly |
| regulation of cation channel activity |
| cell-cell junction |
| regulation of signaling receptor activity |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| production of molecular mediator of immune response |
| regulation of actin polymerization or depolymerization |
| protein localization to plasma membrane |
| regulation of actin filament length |
| protein C-terminus binding |
| regulation of protein localization to membrane |
| cell cycle checkpoint |
| negative regulation of cell activation |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| basolateral plasma membrane |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| protein dephosphorylation |
| cell junction organization |
| regulation of protein kinase B signaling |
| positive regulation of cytoskeleton organization |
| regulation of leukocyte proliferation |
| regulation of protein polymerization |
| membrane raft |
| protein localization to cell periphery |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of muscle system process |
| regulation of stress-activated protein kinase signaling cascade |
| skeletal system morphogenesis |
| cell recognition |
| actin filament organization |
| regulation of heart contraction |
| positive regulation of protein complex assembly |
| muscle contraction |
| protein-containing complex localization |
| regulation of ion transmembrane transporter activity |
| regulation of actin filament organization |
| regulation of transmembrane transporter activity |
| lymphocyte mediated immunity |
| kidney development |
| synapse organization |
| negative regulation of cell adhesion |
| positive regulation of ion transport |
| regulation of transporter activity |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| renal system development |
| regulation of blood circulation |
| embryonic organ morphogenesis |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| muscle tissue development |
| muscle system process |
| epithelial tube morphogenesis |
| negative regulation of mitotic cell cycle |
| dephosphorylation |
| cadherin binding |
| purine ribonucleotide metabolic process |
| camera-type eye development |
| regulation of T cell activation |
| microtubule |
| urogenital system development |
| apical plasma membrane |
| neuron projection |
| positive regulation of cellular protein localization |
| ribonucleotide metabolic process |
| activation of protein kinase activity |
| purine nucleotide metabolic process |
| regulation of epithelial cell proliferation |
| regulation of cation transmembrane transport |
| ribose phosphate metabolic process |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| eye development |
| visual system development |
| establishment of organelle localization |
| sensory system development |
| purine-containing compound metabolic process |
| MAPK cascade |
| regulation of cellular component size |
| lymphocyte activation |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| negative regulation of protein phosphorylation |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| reproductive structure development |
| reproductive system development |
| regulation of membrane potential |
| morphogenesis of an epithelium |
| embryonic organ development |
| trans-synaptic signaling |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| synaptic signaling |
| protein kinase binding |
| microtubule cytoskeleton organization |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| skeletal system development |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| regulation of cellular protein localization |
| nucleobase-containing small molecule metabolic process |
| regulation of cytoskeleton organization |
| sensory organ development |
| cell junction |
| cell population proliferation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| organelle localization |
| regulation of system process |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| regulation of leukocyte activation |
| adaptive immune response |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| microtubule-based process |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| mitotic cell cycle |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| viral process |
| protein localization to organelle |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| symbiotic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| tube development |
| membrane organization |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| organophosphate metabolic process |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| endoplasmic reticulum membrane |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| Golgi apparatus |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| carbohydrate derivative metabolic process |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | -1.72 |
| Cabazitaxel 0.001μM R05 exp223 | -1.7 |
| Tanespimycin 14μM R08 exp527 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12075
- Expression level (log2 read counts): 6.77
Expression Distribution
DLG1 Expression in NALM6 Cells: 6.77
