DLL3
Gene Information
- Official Symbol: DLL3
- Official Name: delta like canonical Notch ligand 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10683
- UniProt: Q9NYJ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5171
- Expression level (log2 read counts): 2.39
DLL3 Expression in NALM6 Cells: 2.39
