DLST

Entrez Summary: This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000250|UniProtKB:Q9N0F1, ECO:0000269|PubMed:29211711}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 10/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Biotin lipoyl
2-oxoacid dh

dihydrolipoyllysine-residue succinyltransferase activity
L-lysine catabolic process to acetyl-CoA via saccharopine
L-lysine metabolic process
protein succinylation
L-lysine catabolic process to acetyl-CoA
histone succinylation
L-lysine catabolic process
oxoglutarate dehydrogenase complex
succinyl-CoA metabolic process
lysine catabolic process
lysine metabolic process
2-oxoglutarate metabolic process
aspartate family amino acid catabolic process
acetyl-CoA metabolic process
tricarboxylic acid cycle
aspartate family amino acid metabolic process
aerobic respiration
acyl-CoA metabolic process
dicarboxylic acid metabolic process
thioester metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
drug catabolic process
cellular respiration
protein acylation
alpha-amino acid metabolic process
energy derivation by oxidation of organic compounds
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process