DNAAF1

Entrez Summary: The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. {ECO:0000269|PubMed:18385425, ECO:0000269|PubMed:19944400, ECO:0000269|PubMed:19944405}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.92
SGC2043 10μM R03 exp152	1.92

determination of pancreatic left/right asymmetry
determination of liver left/right asymmetry
determination of digestive tract left/right asymmetry
epithelial cilium movement involved in determination of left/right asymmetry
regulation of cilium beat frequency
inner dynein arm assembly
regulation of cilium movement
outer dynein arm assembly
left/right pattern formation
dynein complex binding
motile cilium assembly
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
regulation of microtubule-based movement
axonemal dynein complex assembly
heart looping
cilium movement
axoneme assembly
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
pancreas development
embryonic heart tube development
microtubule bundle formation
axoneme
determination of left/right symmetry
spindle pole
determination of bilateral symmetry
specification of symmetry
liver development
hepaticobiliary system development
digestive tract development
digestive system development
lung development
respiratory tube development
microtubule-based transport
respiratory system development
regulation of microtubule-based process
heart morphogenesis
microtubule-based movement
embryonic organ morphogenesis