DNAH11

Entrez Summary: This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013].
UniProt Summary: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

9+0 motile cilium
proximal portion of axoneme
determination of left/right asymmetry in nervous system
sperm flagellum movement involved in flagellated sperm motility
9+2 motile cilium
epithelial cilium movement involved in determination of left/right asymmetry
regulation of cilium beat frequency
regulation of cilium movement
cilium movement involved in cell motility
ATP-dependent microtubule motor activity, minus-end-directed
dynein complex
dynein light chain binding
epithelial cilium movement involved in extracellular fluid movement
dynein light intermediate chain binding
dynein intermediate chain binding
extracellular transport
regulation of microtubule-based movement
cilium movement
determination of heart left/right asymmetry
sperm motility
flagellated sperm motility
cardiac septum morphogenesis
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
axoneme
cardiac septum development
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
cardiac chamber morphogenesis
cardiac chamber development
microtubule-based transport
regulation of microtubule-based process
heart morphogenesis
learning or memory
microtubule-based movement
cognition
microtubule
pattern specification process
heart development