DNAH1 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAH1
  * **<color #00a2e8>Official Name</color>**: dynein axonemal heavy chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25981|25981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2D7|Q9P2D7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 8|
|MT|
|AAA 9|
|AAA 6|
|Dynein heavy|
|AAA 5|
|DHC N2|
|AAA 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inner dynein arm|
|axonemal dynein complex|
|sperm axoneme assembly|
|inner dynein arm assembly|
|cilium movement involved in cell motility|
|ATP-dependent microtubule motor activity, minus-end-directed|
|dynein complex|
|dynein light chain binding|
|epithelial cilium movement involved in extracellular fluid movement|
|dynein light intermediate chain binding|
|dynein intermediate chain binding|
|extracellular transport|
|axonemal dynein complex assembly|
|sperm flagellum|
|cilium movement|
|axoneme assembly|
|microtubule motor activity|
|sperm motility|
|flagellated sperm motility|
|microtubule bundle formation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|axoneme|
|spermatid development|
|spermatid differentiation|
|microtubule-based transport|
|germ cell development|
|microtubule-based movement|
|microtubule|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|reproductive process|
|reproduction|
|ATP binding|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cell development|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11717
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAH1 Expression in NALM6 Cells: 4.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>