DNAH1

Entrez Summary: This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

inner dynein arm
axonemal dynein complex
sperm axoneme assembly
inner dynein arm assembly
cilium movement involved in cell motility
ATP-dependent microtubule motor activity, minus-end-directed
dynein complex
dynein light chain binding
epithelial cilium movement involved in extracellular fluid movement
dynein light intermediate chain binding
dynein intermediate chain binding
extracellular transport
axonemal dynein complex assembly
sperm flagellum
cilium movement
axoneme assembly
microtubule motor activity
sperm motility
flagellated sperm motility
microtubule bundle formation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
axoneme
spermatid development
spermatid differentiation
microtubule-based transport
germ cell development
microtubule-based movement
microtubule
cilium assembly
cellular process involved in reproduction in multicellular organism
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation