DNAJA1 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJA1
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3301|3301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31689|P31689]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
|DnaJ C|
|DnaJ CXXCXGXG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|
|regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway|
|cytoplasmic side of endoplasmic reticulum membrane|
|C3HC4-type RING finger domain binding|
|negative regulation of establishment of protein localization to mitochondrion|
|Tat protein binding|
|negative regulation of JUN kinase activity|
|low-density lipoprotein particle receptor binding|
|ATPase activator activity|
|androgen receptor signaling pathway|
|negative regulation of JNK cascade|
|toxin transport|
|DNA damage response, detection of DNA damage|
|Hsp70 protein binding|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|positive regulation of ATPase activity|
|G protein-coupled receptor binding|
|intracellular steroid hormone receptor signaling pathway|
|flagellated sperm motility|
|sperm motility|
|regulation of establishment of protein localization to mitochondrion|
|negative regulation of protein ubiquitination|
|negative regulation of MAP kinase activity|
|protein localization to mitochondrion|
|regulation of ATPase activity|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of JUN kinase activity|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|negative regulation of intrinsic apoptotic signaling pathway|
|chaperone binding|
|response to heat|
|negative regulation of cellular protein localization|
|steroid hormone mediated signaling pathway|
|unfolded protein binding|
|negative regulation of protein serine/threonine kinase activity|
|microtubule cytoskeleton|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|intracellular receptor signaling pathway|
|negative regulation of MAPK cascade|
|hormone-mediated signaling pathway|
|response to temperature stimulus|
|regulation of JNK cascade|
|negative regulation of establishment of protein localization|
|response to topologically incorrect protein|
|cellular response to steroid hormone stimulus|
|regulation of protein ubiquitination|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|ubiquitin protein ligase binding|
|response to steroid hormone|
|regulation of MAP kinase activity|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|detection of stimulus|
|gamete generation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of protein transport|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of transferase activity|
|multi-organism reproductive process|
|negative regulation of cell death|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.04|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.96|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.88|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.85|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.78|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.71|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.72|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.74|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.12|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.15|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.22|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.3|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.46|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1928
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJA1 Expression in NALM6 Cells: 7.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>