DNAJA1
Gene Information
- Official Symbol: DNAJA1
- Official Name: DnaJ heat shock protein family (Hsp40) member A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3301
- UniProt: P31689
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
Pfam Domains GO Terms
Pfam Domains
| DnaJ |
| DnaJ C |
| DnaJ CXXCXGXG |
GO Terms
| negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
| regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
| cytoplasmic side of endoplasmic reticulum membrane |
| C3HC4-type RING finger domain binding |
| negative regulation of establishment of protein localization to mitochondrion |
| Tat protein binding |
| negative regulation of JUN kinase activity |
| low-density lipoprotein particle receptor binding |
| ATPase activator activity |
| androgen receptor signaling pathway |
| negative regulation of JNK cascade |
| toxin transport |
| DNA damage response, detection of DNA damage |
| Hsp70 protein binding |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| positive regulation of ATPase activity |
| G protein-coupled receptor binding |
| intracellular steroid hormone receptor signaling pathway |
| flagellated sperm motility |
| sperm motility |
| regulation of establishment of protein localization to mitochondrion |
| negative regulation of protein ubiquitination |
| negative regulation of MAP kinase activity |
| protein localization to mitochondrion |
| regulation of ATPase activity |
| negative regulation of protein modification by small protein conjugation or removal |
| regulation of JUN kinase activity |
| cilium or flagellum-dependent cell motility |
| cilium-dependent cell motility |
| negative regulation of intrinsic apoptotic signaling pathway |
| chaperone binding |
| response to heat |
| negative regulation of cellular protein localization |
| steroid hormone mediated signaling pathway |
| unfolded protein binding |
| negative regulation of protein serine/threonine kinase activity |
| microtubule cytoskeleton |
| regulation of intrinsic apoptotic signaling pathway |
| response to unfolded protein |
| intracellular receptor signaling pathway |
| negative regulation of MAPK cascade |
| hormone-mediated signaling pathway |
| response to temperature stimulus |
| regulation of JNK cascade |
| negative regulation of establishment of protein localization |
| response to topologically incorrect protein |
| cellular response to steroid hormone stimulus |
| regulation of protein ubiquitination |
| negative regulation of protein kinase activity |
| negative regulation of apoptotic signaling pathway |
| regulation of protein modification by small protein conjugation or removal |
| protein folding |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| ubiquitin protein ligase binding |
| response to steroid hormone |
| regulation of MAP kinase activity |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| spermatogenesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| male gamete generation |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| detection of stimulus |
| gamete generation |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of protein transport |
| protein localization to organelle |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of transferase activity |
| multi-organism reproductive process |
| negative regulation of cell death |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| localization of cell |
| cell motility |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| regulation of cell death |
| cellular response to stress |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.417 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1928
- Expression level (log2 read counts): 7.96
Expression Distribution
DNAJA1 Expression in NALM6 Cells: 7.96
