DNAJB11 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DNAJB11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJB11
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member B11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51726|51726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBS4|Q9UBS4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJB11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJB11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611341|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
|DnaJ C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IRE1-mediated unfolded protein response|
|positive regulation of ATPase activity|
|regulation of ATPase activity|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|protein maturation|
|protein folding|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|positive regulation of hydrolase activity|
|endoplasmic reticulum|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|cellular response to stress|
|positive regulation of molecular function|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.64|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.43|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.29|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.25|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.13|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.08|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.08|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.03|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.03|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.9|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.85|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.79|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.7|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.81|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.91|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.93|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc3|DNAJC3]]|0.598|
|[[:human genes:u:ube2j1|UBE2J1]]|0.547|
|[[:human genes:a:alg5|ALG5]]|0.538|
|[[:human genes:a:alg6|ALG6]]|0.519|
|[[:human genes:c:c1orf27|C1orf27]]|0.506|
|[[:human genes:m:manf|MANF]]|0.506|
|[[:human genes:s:sec62|SEC62]]|0.505|
|[[:human genes:u:ufm1|UFM1]]|0.496|
|[[:human genes:u:uba5|UBA5]]|0.491|
|[[:human genes:u:ufc1|UFC1]]|0.484|
|[[:human genes:u:ube2g2|UBE2G2]]|0.481|
|[[:human genes:s:stt3a|STT3A]]|0.475|
|[[:human genes:d:derl1|DERL1]]|0.473|
|[[:human genes:t:tmed10|TMED10]]|0.462|
|[[:human genes:a:alg9|ALG9]]|0.457|
|[[:human genes:u:ufsp2|UFSP2]]|0.452|
|[[:human genes:s:slc33a1|SLC33A1]]|0.446|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.439|
|[[:human genes:r:rnmt|RNMT]]|0.439|
|[[:human genes:d:dpm1|DPM1]]|0.436|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.433|
|[[:human genes:d:derl2|DERL2]]|0.43|
|[[:human genes:a:alg8|ALG8]]|0.422|
|[[:human genes:a:alg1|ALG1]]|0.412|
|[[:human genes:a:aup1|AUP1]]|0.412|
|[[:human genes:d:dhrsx|DHRSX]]|0.411|
|[[:human genes:a:aars|AARS]]|0.411|
|[[:human genes:p:pmm2|PMM2]]|0.404|
|[[:human genes:d:dpm3|DPM3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13604
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJB11 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>