DNAJB11
Gene Information
- Official Symbol: DNAJB11
- Official Name: DnaJ heat shock protein family (Hsp40) member B11
- Aliases and Previous Symbols: N/A
- Entrez ID: 51726
- UniProt: Q9UBS4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014].
- UniProt Summary: Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13604
- Expression level (log2 read counts): 7.39
DNAJB11 Expression in NALM6 Cells: 7.39
