DNAJB13

Entrez Summary: This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. [provided by RefSeq, Apr 2017].
UniProt Summary: May play a role in the formation of the central complex of ciliary and flagellar axonemes. {ECO:0000269|PubMed:27486783}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DnaJ
DnaJ C

axonemal central apparatus assembly
sperm connecting piece
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
de novo protein folding
sperm flagellum
chaperone-mediated protein folding
axoneme assembly
microtubule bundle formation
motile cilium
chaperone binding
axoneme
unfolded protein binding
protein folding
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
microtubule-based process
organelle assembly
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization