DNAJC19 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC19
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131118|131118]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DA6|Q96DA6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608977|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PAM complex, Tim23 associated import motor|
|protein import into mitochondrial matrix|
|ATPase activator activity|
|protein transmembrane import into intracellular organelle|
|genitalia development|
|intracellular protein transmembrane transport|
|positive regulation of ATPase activity|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|regulation of ATPase activity|
|mitochondrial transmembrane transport|
|protein import|
|mitochondrial transport|
|visual perception|
|sensory perception of light stimulus|
|protein folding|
|sex differentiation|
|protein targeting|
|mitochondrial inner membrane|
|reproductive structure development|
|reproductive system development|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein-containing complex|
|developmental process involved in reproduction|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|sensory perception|
|intracellular protein transport|
|mitochondrion|
|regulation of hydrolase activity|
|transmembrane transport|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.71|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.77|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.79|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.83|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1573
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC19 Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>