DNAJC19

Entrez Summary: The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012].
UniProt Summary: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PAM complex, Tim23 associated import motor
protein import into mitochondrial matrix
ATPase activator activity
protein transmembrane import into intracellular organelle
genitalia development
intracellular protein transmembrane transport
positive regulation of ATPase activity
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
regulation of ATPase activity
mitochondrial transmembrane transport
protein import
mitochondrial transport
visual perception
sensory perception of light stimulus
protein folding
sex differentiation
protein targeting
mitochondrial inner membrane
reproductive structure development
reproductive system development
establishment of protein localization to organelle
mitochondrion organization
protein-containing complex
developmental process involved in reproduction
protein localization to organelle
positive regulation of hydrolase activity
sensory perception
intracellular protein transport
mitochondrion
regulation of hydrolase activity
transmembrane transport
nervous system process
reproductive process
reproduction
positive regulation of catalytic activity
protein transport
intracellular transport