DNAJC24 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC24
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=120526|120526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P3W2|Q6P3W2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199, ECO:0000269|PubMed:22509046}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CSL|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-diphthamide metabolic process|
|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|
|regulation of cytoplasmic translational elongation|
|peptidyl-histidine modification|
|regulation of translational elongation|
|ATPase activator activity|
|ferrous iron binding|
|regulation of cytoplasmic translation|
|positive regulation of ATPase activity|
|chaperone-mediated protein folding|
|regulation of ATPase activity|
|protein folding|
|regulation of translation|
|cytoskeleton|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|positive regulation of hydrolase activity|
|zinc ion binding|
|peptidyl-amino acid modification|
|oxidation-reduction process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.28|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.91|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.83|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.78|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.8|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.81|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.82|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.83|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.83|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.83|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.86|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.9|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.02|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.05|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.06|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.08|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.17|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.18|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.19|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.22|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.24|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.37|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.65|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.74|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.98|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|3.19|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.31|
|[[:results:exp274|Citral 50μM R06 exp274]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dph1|DPH1]]|0.749|
|[[:human genes:d:dph5|DPH5]]|0.692|
|[[:human genes:d:dph2|DPH2]]|0.69|
|[[:human genes:d:dph6|DPH6]]|0.572|
|[[:human genes:d:dph3|DPH3]]|0.498|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC24 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>