DNAJC24

Entrez Summary: N/A
UniProt Summary: Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199, ECO:0000269|PubMed:22509046}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-CSL
DnaJ

peptidyl-diphthamide metabolic process
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
regulation of cytoplasmic translational elongation
peptidyl-histidine modification
regulation of translational elongation
ATPase activator activity
ferrous iron binding
regulation of cytoplasmic translation
positive regulation of ATPase activity
chaperone-mediated protein folding
regulation of ATPase activity
protein folding
regulation of translation
cytoskeleton
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
positive regulation of hydrolase activity
zinc ion binding
peptidyl-amino acid modification
oxidation-reduction process
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function