DPH2

Entrez Summary: N/A
UniProt Summary: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250|UniProtKB:Q9CR25}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.84
Demecolcine 0.03μM R05 exp228	-2.69
BI-2536 0.0042μM R03 exp95	-2.51
LY2090314 0.003μM R08 exp500 no dilution day6	-2.5
Nicotine 3000μM R08 exp510	-2.42
BML-284 0.09μM R08 exp460	-2.11
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.08
Colchicine 0.009μM R05 exp215	-1.91
Etoposide 1μM R00 exp19	-1.84
Apcin 50 to 100μM on day4 R04 exp176	-1.82
BI-6727 0.0125μM R03 exp97	-1.82
Vincristine 0.0005μM R04 exp190	-1.79
GSK461364A 0.005μM R03 exp125	-1.75
Rifampicin 1μM R00 exp31	-1.74
Vinblastine 0.015μM R05 exp208	1.7
UM0125461 0.74μM R02 exp84	1.77
FK-506 30μM R07 exp359	1.83
Docetaxel 0.002μM R01 exp45	1.89
GSK-J4 1-1.25μM to day4 R07 exp363	2.51
Citral 75μM R06 exp275	2.76
Citral 50μM R06 exp274	2.99
UM0129480 7μM R02 exp85	3.47

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-(3-amino-3-carboxypropyl)histidine synthase activity
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
peptidyl-diphthamide metabolic process
regulation of cytoplasmic translational elongation
peptidyl-histidine modification
regulation of translational elongation
regulation of cytoplasmic translation
regulation of translation
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
peptidyl-amino acid modification