DNAJC27

Entrez Summary: N/A
UniProt Summary: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. {ECO:0000250|UniProtKB:Q8CFP6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of MAPK export from nucleus
regulation of protein export from nucleus
Rab protein signal transduction
regulation of nucleocytoplasmic transport
positive regulation of ERK1 and ERK2 cascade
regulation of intracellular protein transport
Ras protein signal transduction
regulation of ERK1 and ERK2 cascade
small GTPase mediated signal transduction
GTPase activity
regulation of intracellular transport
GTP binding
regulation of cellular protein localization
positive regulation of MAPK cascade
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of MAPK cascade
regulation of cellular localization
intracellular protein transport
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
regulation of protein localization
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
regulation of phosphorylation
cellular macromolecule localization
positive regulation of cellular protein metabolic process
establishment of protein localization
positive regulation of signal transduction
intracellular signal transduction
positive regulation of protein metabolic process