DNAJC9 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJC9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC9
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23234|23234]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WXX5|Q8WXX5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. {ECO:0000269|PubMed:17182002}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ATPase activity|
|heat shock protein binding|
|regulation of ATPase activity|
|positive regulation of hydrolase activity|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|extracellular space|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.51|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.2|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.08|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.07|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.95|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.88|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.88|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 464/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|21/28|
|bone|19/26|
|breast|19/33|
|central nervous system|39/56|
|cervix|1/4|
|colorectal|6/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|15/21|
|liver|12/20|
|lung|46/75|
|lymphocyte|14/16|
|ovary|17/26|
|pancreas|10/24|
|peripheral nervous system|13/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|18/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 453
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC9 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>