DNASE2

Entrez Summary: N/A
UniProt Summary: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deoxyribonuclease II activity
apoptotic DNA fragmentation
DNA catabolic process, endonucleolytic
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
DNA catabolic process
execution phase of apoptosis
erythrocyte differentiation
erythrocyte homeostasis
myeloid cell homeostasis
homeostasis of number of cells
myeloid cell differentiation
lysosome
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
cellular component disassembly
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
DNA metabolic process
cellular macromolecule catabolic process
apoptotic process
macromolecule catabolic process
programmed cell death
cell death
regulation of immune response
DNA binding
homeostatic process
regulation of immune system process
organic substance catabolic process
cellular catabolic process