DND1

Entrez Summary: N/A
UniProt Summary: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:18155131}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AU-rich element binding
negative regulation of gene silencing by miRNA
negative regulation of gene silencing by RNA
negative regulation of posttranscriptional gene silencing
miRNA binding
negative regulation of gene silencing
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
mRNA 3-UTR binding
negative regulation of mRNA metabolic process
regulation of gene silencing by miRNA
regulation of posttranscriptional gene silencing
regulation of gene silencing by RNA
regulation of gene silencing
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
negative regulation of cellular catabolic process
germ cell development
negative regulation of catabolic process
regulation of mRNA metabolic process
cellular process involved in reproduction in multicellular organism
posttranscriptional regulation of gene expression
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
regulation of cellular catabolic process
multicellular organism reproduction
multi-organism reproductive process
regulation of catabolic process
negative regulation of RNA metabolic process
RNA binding
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
cell development