DNPH1

Gene Information

Official Symbol: DNPH1
Official Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Aliases and Previous Symbols: N/A
Entrez ID: 10591
UniProt: O43598
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10967
Expression level (log2 read counts): 3.78

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	-4.79
Olaparib 4μM R08 exp512	-3.97
Talazoparib 0.006μM R06 exp299	-2.42

deoxyribonucleoside 5-monophosphate N-glycosidase activity
deoxyribonucleoside monophosphate catabolic process
nucleoside monophosphate catabolic process
deoxyribonucleoside monophosphate metabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside monophosphate metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
organophosphate catabolic process
glycosyl compound metabolic process
positive regulation of cell growth
positive regulation of growth
purine nucleotide metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
regulation of cell growth
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
regulation of growth
epithelial cell differentiation
protein homodimerization activity
organophosphate metabolic process
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
identical protein binding
nucleobase-containing compound biosynthetic process
epithelium development
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process