DNTT [The Human Chemical-Genetic Interaction Map Project]

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======= DNTT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNTT
  * **<color #00a2e8>Official Name</color>**: DNA nucleotidylexotransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1791|1791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04053|P04053]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNTT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNTT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. {ECO:0000250|UniProtKB:P09838}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol lambd f|
|NTP transf 2|
|BRCT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA nucleotidylexotransferase activity|
|euchromatin|
|DNA-directed DNA polymerase activity|
|response to ATP|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|DNA modification|
|nuclear matrix|
|DNA biosynthetic process|
|response to organophosphorus|
|response to purine-containing compound|
|double-strand break repair|
|response to nutrient|
|nuclear chromatin|
|response to nutrient levels|
|DNA repair|
|response to extracellular stimulus|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.76|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNTT Expression in NALM6 Cells: 8.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>