DOC2A
Gene Information
- Official Symbol: DOC2A
- Official Name: double C2 domain alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 8448
- UniProt: Q14183
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4549
- Expression level (log2 read counts): 3.21