DOK1

Entrez Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
UniProt Summary: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK461364A 0.005μM R03 exp125	1.81
Cerivastatin 0.15μM R05 exp226	1.88

macrophage colony-stimulating factor signaling pathway
cellular response to macrophage colony-stimulating factor stimulus
response to macrophage colony-stimulating factor
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERBB signaling pathway
regulation of epidermal growth factor receptor signaling pathway
regulation of ERBB signaling pathway
Ras protein signal transduction
axon guidance
neuron projection guidance
small GTPase mediated signal transduction
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
cytokine-mediated signaling pathway
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
cell morphogenesis
neuron development
cellular component morphogenesis
cellular response to cytokine stimulus
neuron differentiation
response to cytokine
plasma membrane bounded cell projection organization
cell projection organization
locomotion
generation of neurons
movement of cell or subcellular component
neurogenesis
cell development
positive regulation of signal transduction