DOK5

Entrez Summary: N/A
UniProt Summary: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of neurotrophin TRK receptor signaling pathway
axon guidance
neuron projection guidance
regulation of cellular response to growth factor stimulus
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
positive regulation of MAPK cascade
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
enzyme linked receptor protein signaling pathway
cell morphogenesis
regulation of MAPK cascade
neuron development
cellular component morphogenesis
neuron differentiation
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
plasma membrane bounded cell projection organization
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
cell projection organization
positive regulation of protein modification process
locomotion
regulation of protein phosphorylation
generation of neurons
movement of cell or subcellular component
regulation of phosphorylation
positive regulation of cellular protein metabolic process
neurogenesis
cell development
positive regulation of signal transduction