DOLK [The Human Chemical-Genetic Interaction Map Project]

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======= DOLK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOLK
  * **<color #00a2e8>Official Name</color>**: dolichol kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22845|22845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPQ8|Q9UPQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOLK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOLK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl monophosphate biosynthetic process|
|dolichol kinase activity|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|protein N-linked glycosylation|
|integral component of endoplasmic reticulum membrane|
|phospholipid biosynthetic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.11|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.96|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.84|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.8|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.77|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srd5a3|SRD5A3]]|0.664|
|[[:human genes:d:dpagt1|DPAGT1]]|0.657|
|[[:human genes:a:alg1|ALG1]]|0.634|
|[[:human genes:d:dhrsx|DHRSX]]|0.617|
|[[:human genes:t:thg1l|THG1L]]|0.593|
|[[:human genes:a:alg6|ALG6]]|0.571|
|[[:human genes:a:atxn10|ATXN10]]|0.555|
|[[:human genes:r:rft1|RFT1]]|0.549|
|[[:human genes:k:kdsr|KDSR]]|0.548|
|[[:human genes:u:uap1|UAP1]]|0.547|
|[[:human genes:g:gfpt1|GFPT1]]|0.538|
|[[:human genes:s:ssb|SSB]]|0.531|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.52|
|[[:human genes:p:pmm2|PMM2]]|0.519|
|[[:human genes:a:adsl|ADSL]]|0.518|
|[[:human genes:r:rtcb|RTCB]]|0.517|
|[[:human genes:f:fh|FH]]|0.517|
|[[:human genes:t:triap1|TRIAP1]]|0.513|
|[[:human genes:p:pgm3|PGM3]]|0.513|
|[[:human genes:u:ube2g2|UBE2G2]]|0.508|
|[[:human genes:d:dohh|DOHH]]|0.507|
|[[:human genes:r:rpp21|RPP21]]|0.505|
|[[:human genes:v:vezt|VEZT]]|0.505|
|[[:human genes:a:atp5j|ATP5J]]|0.501|
|[[:human genes:a:atic|ATIC]]|0.5|
|[[:human genes:a:atp5b|ATP5B]]|0.499|
|[[:human genes:l:lsm10|LSM10]]|0.495|
|[[:human genes:g:gmppb|GMPPB]]|0.493|
|[[:human genes:a:atp5o|ATP5O]]|0.491|
|[[:human genes:s:srp14|SRP14]]|0.489|
|[[:human genes:a:alg5|ALG5]]|0.487|
|[[:human genes:d:ddx1|DDX1]]|0.487|
|[[:human genes:a:atp2a2|ATP2A2]]|0.486|
|[[:human genes:r:rpia|RPIA]]|0.483|
|[[:human genes:p:ppa2|PPA2]]|0.482|
|[[:human genes:t:trmt61a|TRMT61A]]|0.482|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.477|
|[[:human genes:d:dars2|DARS2]]|0.475|
|[[:human genes:u:uhrf1|UHRF1]]|0.473|
|[[:human genes:t:timm22|TIMM22]]|0.473|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.47|
|[[:human genes:m:mbtps2|MBTPS2]]|0.469|
|[[:human genes:t:tsen54|TSEN54]]|0.468|
|[[:human genes:c:ccdc115|CCDC115]]|0.467|
|[[:human genes:e:elp3|ELP3]]|0.467|
|[[:human genes:r:rptor|RPTOR]]|0.467|
|[[:human genes:r:rabggtb|RABGGTB]]|0.466|
|[[:human genes:p:ppcdc|PPCDC]]|0.463|
|[[:human genes:t:trmt6|TRMT6]]|0.463|
|[[:human genes:t:ten1|TEN1]]|0.463|
|[[:human genes:a:alg8|ALG8]]|0.461|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.46|
|[[:human genes:u:uso1|USO1]]|0.459|
|[[:human genes:t:tprkb|TPRKB]]|0.458|
|[[:human genes:p:ppcs|PPCS]]|0.457|
|[[:human genes:u:urm1|URM1]]|0.456|
|[[:human genes:r:rnmt|RNMT]]|0.455|
|[[:human genes:m:mrps33|MRPS33]]|0.452|
|[[:human genes:m:mrps14|MRPS14]]|0.448|
|[[:human genes:e:elp2|ELP2]]|0.448|
|[[:human genes:m:med16|MED16]]|0.447|
|[[:human genes:r:romo1|ROMO1]]|0.446|
|[[:human genes:c:c15orf41|C15orf41]]|0.446|
|[[:human genes:s:sec62|SEC62]]|0.446|
|[[:human genes:v:vma21|VMA21]]|0.445|
|[[:human genes:f:flvcr1|FLVCR1]]|0.445|
|[[:human genes:w:wdr92|WDR92]]|0.444|
|[[:human genes:e:eny2|ENY2]]|0.444|
|[[:human genes:l:lsmd1|LSMD1]]|0.442|
|[[:human genes:t:tmed10|TMED10]]|0.44|
|[[:human genes:c:c10orf2|C10orf2]]|0.439|
|[[:human genes:g:gemin8|GEMIN8]]|0.438|
|[[:human genes:e:elac2|ELAC2]]|0.437|
|[[:human genes:d:dnlz|DNLZ]]|0.436|
|[[:human genes:p:pik3r4|PIK3R4]]|0.435|
|[[:human genes:b:bcs1l|BCS1L]]|0.435|
|[[:human genes:d:dap3|DAP3]]|0.434|
|[[:human genes:f:fen1|FEN1]]|0.434|
|[[:human genes:n:nae1|NAE1]]|0.434|
|[[:human genes:u:uba5|UBA5]]|0.433|
|[[:human genes:a:alg13|ALG13]]|0.432|
|[[:human genes:g:gemin6|GEMIN6]]|0.431|
|[[:human genes:c:cdipt|CDIPT]]|0.429|
|[[:human genes:y:yars2|YARS2]]|0.428|
|[[:human genes:p:psmg2|PSMG2]]|0.427|
|[[:human genes:r:rfk|RFK]]|0.427|
|[[:human genes:e:exoc4|EXOC4]]|0.425|
|[[:human genes:e:eef1e1|EEF1E1]]|0.425|
|[[:human genes:a:atp5c1|ATP5C1]]|0.424|
|[[:human genes:t:trmt10a|TRMT10A]]|0.424|
|[[:human genes:z:zrsr2|ZRSR2]]|0.423|
|[[:human genes:m:mrp63|MRP63]]|0.423|
|[[:human genes:d:dr1|DR1]]|0.422|
|[[:human genes:m:med4|MED4]]|0.422|
|[[:human genes:p:pars2|PARS2]]|0.422|
|[[:human genes:a:atrx|ATRX]]|0.421|
|[[:human genes:m:mocs3|MOCS3]]|0.421|
|[[:human genes:a:atp5a1|ATP5A1]]|0.421|
|[[:human genes:g:gemin7|GEMIN7]]|0.421|
|[[:human genes:p:ppp4c|PPP4C]]|0.42|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.42|
|[[:human genes:m:mrpl23|MRPL23]]|0.418|
|[[:human genes:c:chka|CHKA]]|0.416|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.416|
|[[:human genes:m:mrps6|MRPS6]]|0.415|
|[[:human genes:a:alg3|ALG3]]|0.415|
|[[:human genes:s:sec63|SEC63]]|0.414|
|[[:human genes:u:uba3|UBA3]]|0.413|
|[[:human genes:t:tbcb|TBCB]]|0.413|
|[[:human genes:t:ttc4|TTC4]]|0.412|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.411|
|[[:human genes:c:cbfb|CBFB]]|0.411|
|[[:human genes:c:chchd4|CHCHD4]]|0.41|
|[[:human genes:p:pggt1b|PGGT1B]]|0.409|
|[[:human genes:n:nbn|NBN]]|0.409|
|[[:human genes:m:mbtps1|MBTPS1]]|0.409|
|[[:human genes:d:dpm3|DPM3]]|0.408|
|[[:human genes:p:psmg4|PSMG4]]|0.407|
|[[:human genes:t:trnt1|TRNT1]]|0.406|
|[[:human genes:p:pelo|PELO]]|0.406|
|[[:human genes:g:gfm1|GFM1]]|0.406|
|[[:human genes:e:eif1ax|EIF1AX]]|0.405|
|[[:human genes:a:alg9|ALG9]]|0.405|
|[[:human genes:m:mrps2|MRPS2]]|0.404|
|[[:human genes:a:alg14|ALG14]]|0.404|
|[[:human genes:h:hspd1|HSPD1]]|0.403|
|[[:human genes:p:pmvk|PMVK]]|0.402|
|[[:human genes:d:dnajc3|DNAJC3]]|0.402|
|[[:human genes:t:trmt5|TRMT5]]|0.401|
|[[:human genes:u:utp23|UTP23]]|0.401|
|[[:human genes:a:atp5h|ATP5H]]|0.401|
|[[:human genes:m:med25|MED25]]|0.4|
|[[:human genes:m:msto1|MSTO1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 67/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|1/28|
|blood|4/28|
|bone|3/26|
|breast|1/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|4/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 306
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOLK Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>