DOLK

Entrez Summary: The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010].
UniProt Summary: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
L-74142 5μM R03 exp131	-2.11
Nicotine 3000μM R08 exp510	-2
A-366 10μM R03 exp115	-1.96
Apcin 50 to 100μM on day4 R04 exp176	-1.84
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.8
Oligomycin-A 20μM R00 exp26	1.7
Amiloride 100μM R08 exp447	1.72
ONC212 0.15μM R08 exp513	1.77
TIC10 10μM R08 exp532	1.89

Global Fraction of Cell Lines Where Essential: 67/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	1/28
blood	4/28
bone	3/26
breast	1/33
central nervous system	5/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	4/20
lung	7/75
lymphocyte	0/16
ovary	1/26
pancreas	2/24
peripheral nervous system	3/16
plasma cell	1/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	1/5

Expression Distribution

dolichyl monophosphate biosynthetic process
dolichol kinase activity
dolichyl diphosphate metabolic process
dolichyl diphosphate biosynthetic process
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
integral component of endoplasmic reticulum membrane
phospholipid biosynthetic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
phospholipid metabolic process
glycoprotein metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
phosphorylation
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process