DONSON [The Human Chemical-Genetic Interaction Map Project]

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======= DONSON =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DONSON
  * **<color #00a2e8>Official Name</color>**: DNA replication fork stabilization factor DONSON
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29980|29980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYP3|Q9NYP3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DONSON&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DONSON|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|replisome|
|replication fork protection|
|mitotic G2 DNA damage checkpoint|
|replication fork|
|negative regulation of DNA-dependent DNA replication|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|negative regulation of DNA replication|
|DNA-dependent DNA replication maintenance of fidelity|
|nuclear DNA replication|
|cell cycle DNA replication|
|regulation of DNA-dependent DNA replication|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|regulation of DNA replication|
|DNA-dependent DNA replication|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|DNA replication|
|negative regulation of cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.77|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.57|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.52|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.16|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.07|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.92|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.71|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.72|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.76|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.78|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.84|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.89|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.91|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.94|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.03|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.12|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.19|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.22|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.28|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.39|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.4|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.476|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1136
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DONSON Expression in NALM6 Cells: 5.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>