DONSON

Entrez Summary: N/A
UniProt Summary: Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 738/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

replisome
replication fork protection
mitotic G2 DNA damage checkpoint
replication fork
negative regulation of DNA-dependent DNA replication
mitotic G2/M transition checkpoint
G2 DNA damage checkpoint
negative regulation of DNA replication
DNA-dependent DNA replication maintenance of fidelity
nuclear DNA replication
cell cycle DNA replication
regulation of DNA-dependent DNA replication
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
regulation of DNA replication
DNA-dependent DNA replication
DNA damage checkpoint
DNA integrity checkpoint
mitotic cell cycle checkpoint
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
DNA replication
negative regulation of cell cycle phase transition
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
DNA metabolic process
regulation of cell cycle process
cellular response to DNA damage stimulus
cell cycle process
regulation of cell cycle