DPCD [The Human Chemical-Genetic Interaction Map Project]

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======= DPCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPCD
  * **<color #00a2e8>Official Name</color>**: deleted in primary ciliary dyskinesia homolog (mouse)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25911|25911]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVM2|Q9BVM2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the formation or function of ciliated cells. {ECO:0000269|PubMed:14630615}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|third ventricle development|
|lateral ventricle development|
|left/right pattern formation|
|ventricular system development|
|epithelial cilium movement involved in extracellular fluid movement|
|extracellular transport|
|cilium movement|
|flagellated sperm motility|
|sperm motility|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|microtubule-based transport|
|telencephalon development|
|microtubule-based movement|
|regionalization|
|forebrain development|
|pattern specification process|
|spermatogenesis|
|male gamete generation|
|microtubule-based process|
|gamete generation|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|central nervous system development|
|multi-organism reproductive process|
|cell motility|
|localization of cell|
|locomotion|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8404
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPCD Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>