DPF2 [The Human Chemical-Genetic Interaction Map Project]

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======= DPF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPF2
  * **<color #00a2e8>Official Name</color>**: double PHD fingers 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5977|5977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92785|Q92785]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of myeloid progenitor cell differentiation|
|negative regulation of myeloid progenitor cell differentiation|
|H3K9me3 modified histone binding|
|negative regulation of hematopoietic progenitor cell differentiation|
|nBAF complex|
|lysine-acetylated histone binding|
|histone acetyltransferase complex|
|histone acetyltransferase activity|
|regulation of hematopoietic progenitor cell differentiation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|negative regulation of hemopoiesis|
|protein acetylation|
|protein acylation|
|nuclear chromatin|
|transcription corepressor activity|
|apoptotic signaling pathway|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|centrosome|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|intracellular membrane-bounded organelle|
|chromatin organization|
|negative regulation of cell differentiation|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|apoptotic process|
|negative regulation of developmental process|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.21|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.21|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.06|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.93|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.83|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.82|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.8|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.75|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.74|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.72|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.71|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.93|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.11|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.585|
|[[:human genes:g:gmppb|GMPPB]]|0.535|
|[[:human genes:r:rptor|RPTOR]]|0.531|
|[[:human genes:p:pmm2|PMM2]]|0.525|
|[[:human genes:u:uap1|UAP1]]|0.519|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.513|
|[[:human genes:t:triap1|TRIAP1]]|0.511|
|[[:human genes:r:rtcb|RTCB]]|0.508|
|[[:human genes:a:alg1|ALG1]]|0.502|
|[[:human genes:g:gfpt1|GFPT1]]|0.499|
|[[:human genes:t:thg1l|THG1L]]|0.496|
|[[:human genes:a:atxn10|ATXN10]]|0.488|
|[[:human genes:a:alg5|ALG5]]|0.486|
|[[:human genes:r:rpe|RPE]]|0.484|
|[[:human genes:e:eny2|ENY2]]|0.474|
|[[:human genes:p:pelo|PELO]]|0.473|
|[[:human genes:t:tamm41|TAMM41]]|0.471|
|[[:human genes:d:dpagt1|DPAGT1]]|0.467|
|[[:human genes:d:dhx29|DHX29]]|0.463|
|[[:human genes:a:aars|AARS]]|0.462|
|[[:human genes:t:tsen54|TSEN54]]|0.46|
|[[:human genes:u:utp23|UTP23]]|0.448|
|[[:human genes:d:dhps|DHPS]]|0.448|
|[[:human genes:w:wdr24|WDR24]]|0.447|
|[[:human genes:c:ccdc101|CCDC101]]|0.447|
|[[:human genes:t:tmed10|TMED10]]|0.446|
|[[:human genes:t:tmem41b|TMEM41B]]|0.446|
|[[:human genes:n:nars|NARS]]|0.446|
|[[:human genes:t:timm13|TIMM13]]|0.444|
|[[:human genes:d:dohh|DOHH]]|0.443|
|[[:human genes:e:eif4e|EIF4E]]|0.441|
|[[:human genes:t:thoc6|THOC6]]|0.438|
|[[:human genes:d:dcaf5|DCAF5]]|0.437|
|[[:human genes:r:rnmt|RNMT]]|0.436|
|[[:human genes:s:srp68|SRP68]]|0.434|
|[[:human genes:t:tti2|TTI2]]|0.434|
|[[:human genes:s:srp14|SRP14]]|0.433|
|[[:human genes:c:ctc1|CTC1]]|0.431|
|[[:human genes:c:cbfb|CBFB]]|0.43|
|[[:human genes:e:eif3f|EIF3F]]|0.427|
|[[:human genes:a:atp5j|ATP5J]]|0.426|
|[[:human genes:m:mapk14|MAPK14]]|0.426|
|[[:human genes:u:uhrf1|UHRF1]]|0.424|
|[[:human genes:o:oraov1|ORAOV1]]|0.423|
|[[:human genes:s:sec61g|SEC61G]]|0.422|
|[[:human genes:c:csnk2b|CSNK2B]]|0.421|
|[[:human genes:m:mtor|MTOR]]|0.421|
|[[:human genes:l:lsm11|LSM11]]|0.421|
|[[:human genes:h:hccs|HCCS]]|0.419|
|[[:human genes:t:ten1|TEN1]]|0.419|
|[[:human genes:m:med16|MED16]]|0.418|
|[[:human genes:e:exoc4|EXOC4]]|0.417|
|[[:human genes:z:znf259|ZNF259]]|0.416|
|[[:human genes:p:pggt1b|PGGT1B]]|0.41|
|[[:human genes:r:rpp21|RPP21]]|0.41|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.409|
|[[:human genes:a:alg6|ALG6]]|0.409|
|[[:human genes:m:mars|MARS]]|0.406|
|[[:human genes:a:adsl|ADSL]]|0.405|
|[[:human genes:o:oip5|OIP5]]|0.405|
|[[:human genes:h:hspd1|HSPD1]]|0.404|
|[[:human genes:u:ube2g2|UBE2G2]]|0.403|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.401|
|[[:human genes:d:ddx55|DDX55]]|0.401|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPF2 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>