DPF2
Gene Information
- Official Symbol: DPF2
- Official Name: double PHD fingers 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5977
- UniProt: Q92785
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
Pfam Domains GO Terms
Pfam Domains
| PHD |
GO Terms
| regulation of myeloid progenitor cell differentiation |
| negative regulation of myeloid progenitor cell differentiation |
| H3K9me3 modified histone binding |
| negative regulation of hematopoietic progenitor cell differentiation |
| nBAF complex |
| lysine-acetylated histone binding |
| histone acetyltransferase complex |
| histone acetyltransferase activity |
| regulation of hematopoietic progenitor cell differentiation |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| histone binding |
| negative regulation of hemopoiesis |
| protein acetylation |
| protein acylation |
| nuclear chromatin |
| transcription corepressor activity |
| apoptotic signaling pathway |
| peptidyl-lysine modification |
| histone modification |
| covalent chromatin modification |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| centrosome |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| intracellular membrane-bounded organelle |
| chromatin organization |
| negative regulation of cell differentiation |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| apoptotic process |
| negative regulation of developmental process |
| programmed cell death |
| chromosome organization |
| cell death |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.585 |
| GMPPB | 0.535 |
| RPTOR | 0.531 |
| PMM2 | 0.525 |
| UAP1 | 0.519 |
| GTF3C6 | 0.513 |
| TRIAP1 | 0.511 |
| RTCB | 0.508 |
| ALG1 | 0.502 |
| GFPT1 | 0.499 |
| THG1L | 0.496 |
| ATXN10 | 0.488 |
| ALG5 | 0.486 |
| RPE | 0.484 |
| ENY2 | 0.474 |
| PELO | 0.473 |
| TAMM41 | 0.471 |
| DPAGT1 | 0.467 |
| DHX29 | 0.463 |
| AARS | 0.462 |
| TSEN54 | 0.46 |
| UTP23 | 0.448 |
| DHPS | 0.448 |
| WDR24 | 0.447 |
| CCDC101 | 0.447 |
| TMED10 | 0.446 |
| TMEM41B | 0.446 |
| NARS | 0.446 |
| TIMM13 | 0.444 |
| DOHH | 0.443 |
| EIF4E | 0.441 |
| THOC6 | 0.438 |
| DCAF5 | 0.437 |
| RNMT | 0.436 |
| SRP68 | 0.434 |
| TTI2 | 0.434 |
| SRP14 | 0.433 |
| CTC1 | 0.431 |
| CBFB | 0.43 |
| EIF3F | 0.427 |
| ATP5J | 0.426 |
| MAPK14 | 0.426 |
| UHRF1 | 0.424 |
| ORAOV1 | 0.423 |
| SEC61G | 0.422 |
| CSNK2B | 0.421 |
| MTOR | 0.421 |
| LSM11 | 0.421 |
| HCCS | 0.419 |
| TEN1 | 0.419 |
| MED16 | 0.418 |
| EXOC4 | 0.417 |
| ZNF259 | 0.416 |
| PGGT1B | 0.41 |
| RPP21 | 0.41 |
| GTF3C2 | 0.409 |
| ALG6 | 0.409 |
| MARS | 0.406 |
| ADSL | 0.405 |
| OIP5 | 0.405 |
| HSPD1 | 0.404 |
| UBE2G2 | 0.403 |
| GTF3C3 | 0.401 |
| DDX55 | 0.401 |
| PPP2R3C | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 7/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5757
- Expression level (log2 read counts): 6.42
Expression Distribution
DPF2 Expression in NALM6 Cells: 6.42
