DPH6 [The Human Chemical-Genetic Interaction Map Project]

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======= DPH6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPH6
  * **<color #00a2e8>Official Name</color>**: diphthamine biosynthesis 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=89978|89978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L8W6|Q7L8W6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPH6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPH6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618391|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). {ECO:0000250, ECO:0000269|PubMed:23169644}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP bind 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diphthine-ammonia ligase activity|
|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|
|peptidyl-diphthamide metabolic process|
|regulation of cytoplasmic translational elongation|
|peptidyl-histidine modification|
|regulation of translational elongation|
|regulation of cytoplasmic translation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|nucleolus|
|peptidyl-amino acid modification|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.18|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.89|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.74|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.75|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.82|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.93|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.95|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.96|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.13|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.24|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.36|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.38|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.41|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.45|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.56|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.59|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.67|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.76|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.92|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.02|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.4|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dph5|DPH5]]|0.694|
|[[:human genes:d:dph1|DPH1]]|0.602|
|[[:human genes:d:dnajc24|DNAJC24]]|0.572|
|[[:human genes:d:dph2|DPH2]]|0.546|
|[[:human genes:z:zzz3|ZZZ3]]|0.466|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.465|
|[[:human genes:s:sbds|SBDS]]|0.455|
|[[:human genes:u:urm1|URM1]]|0.437|
|[[:human genes:t:tpt1|TPT1]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7575
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPH6 Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>