DPH6

Entrez Summary: N/A
UniProt Summary: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). {ECO:0000250, ECO:0000269|PubMed:23169644}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.18
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.89
UM0011500 5μM R05 exp245	-1.79
LY2090314 0.003μM R08 exp499	-1.73
Milciclib 2μM R08 exp502	1.74
Citral 75μM R06 exp275	1.75
ML-792 0.2μM R08 exp505	1.82
IU1-C 25μM R04 exp183	1.93
ONC212 0.15μM R08 exp513	1.95
Lead acetate 2000μM R08 exp497	1.96
Sulforaphane 9μM R08 exp525	2.04
Nocodazole 0.1μM R03 exp94	2.13
Aphidicolin 0.4μM R08 exp440	2.24
LLY-283 2.6μM R06 exp290	2.36
Hippuristanol 0.12μM R08 exp488	2.38
GSK-J4 1-1.25μM to day4 R07 exp363	2.41
Resveratrol 16μM R03 exp147	2.45
Sulforaphane 9μM R08 exp526 no dilution day6	2.56
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.59
Citral 50μM R06 exp274	2.67
AICAR 240μM R03 exp116	2.76
MS023 2μM R03 exp134	2.92
MS023 7μM R03 exp135	3.02
Bortezomib 0.005μM R00 exp6	3.4
CB-5083 0.4μM R08 exp468	3.64

Global Fraction of Cell Lines Where Essential: 30/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	1/5

Expression Distribution

diphthine-ammonia ligase activity
peptidyl-diphthamide biosynthetic process from peptidyl-histidine
peptidyl-diphthamide metabolic process
regulation of cytoplasmic translational elongation
peptidyl-histidine modification
regulation of translational elongation
regulation of cytoplasmic translation
regulation of translation
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
nucleolus
peptidyl-amino acid modification
ATP binding