DPPA4
Gene Information
- Official Symbol: DPPA4
- Official Name: developmental pluripotency associated 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 55211
- UniProt: Q7L190
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
- UniProt Summary: May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. {ECO:0000250|UniProtKB:Q8CCG4}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17056
- Expression level (log2 read counts): 3.59
DPPA4 Expression in NALM6 Cells: 3.59
