DPYSL3 [The Human Chemical-Genetic Interaction Map Project]

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======= DPYSL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPYSL3
  * **<color #00a2e8>Official Name</color>**: dihydropyrimidinase like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1809|1809]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14195|Q14195]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPYSL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPYSL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amidohydro 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydropyrimidinase activity|
|pyrimidine nucleobase catabolic process|
|actin crosslink formation|
|chondroitin sulfate binding|
|nucleobase catabolic process|
|filamin binding|
|pyrimidine nucleobase metabolic process|
|exocytic vesicle|
|positive regulation of filopodium assembly|
|filamentous actin|
|nucleobase metabolic process|
|pyrimidine-containing compound catabolic process|
|regulation of filopodium assembly|
|response to axon injury|
|actin filament bundle assembly|
|actin filament bundle organization|
|cell body|
|positive regulation of plasma membrane bounded cell projection assembly|
|pyrimidine-containing compound metabolic process|
|growth cone|
|SH3 domain binding|
|negative regulation of neuron projection development|
|lamellipodium|
|negative regulation of cell projection organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|negative regulation of neuron differentiation|
|actin filament organization|
|negative regulation of cell migration|
|synapse|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|protein homooligomerization|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|organic cyclic compound catabolic process|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|actin filament-based process|
|response to wounding|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|neuron development|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|organonitrogen compound catabolic process|
|response to cytokine|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|protein-containing complex assembly|
|extracellular space|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.458|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPYSL3 Expression in NALM6 Cells: -2.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>