DPYSL3
Gene Information
- Official Symbol: DPYSL3
- Official Name: dihydropyrimidinase like 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 1809
- UniProt: Q14195
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Amidohydro 1 |
GO Terms
| dihydropyrimidinase activity |
| pyrimidine nucleobase catabolic process |
| actin crosslink formation |
| chondroitin sulfate binding |
| nucleobase catabolic process |
| filamin binding |
| pyrimidine nucleobase metabolic process |
| exocytic vesicle |
| positive regulation of filopodium assembly |
| filamentous actin |
| nucleobase metabolic process |
| pyrimidine-containing compound catabolic process |
| regulation of filopodium assembly |
| response to axon injury |
| actin filament bundle assembly |
| actin filament bundle organization |
| cell body |
| positive regulation of plasma membrane bounded cell projection assembly |
| pyrimidine-containing compound metabolic process |
| growth cone |
| SH3 domain binding |
| negative regulation of neuron projection development |
| lamellipodium |
| negative regulation of cell projection organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| negative regulation of neuron differentiation |
| actin filament organization |
| negative regulation of cell migration |
| synapse |
| negative regulation of cell motility |
| positive regulation of neuron projection development |
| negative regulation of neurogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| negative regulation of cell development |
| protein homooligomerization |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| organic cyclic compound catabolic process |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| positive regulation of nervous system development |
| nucleobase-containing small molecule metabolic process |
| positive regulation of cell development |
| actin filament-based process |
| response to wounding |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| neuron development |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| neuron differentiation |
| organonitrogen compound catabolic process |
| response to cytokine |
| cytoskeleton organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of developmental process |
| generation of neurons |
| protein-containing complex assembly |
| extracellular space |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cannabidiol 13μM R08 exp465 | 1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.458 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9747
- Expression level (log2 read counts): -2.96
Expression Distribution
DPYSL3 Expression in NALM6 Cells: -2.96
