DPYSL4

Entrez Summary: N/A
UniProt Summary: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dihydropyrimidinase activity
pyrimidine nucleobase catabolic process
nucleobase catabolic process
filamin binding
pyrimidine nucleobase metabolic process
nucleobase metabolic process
pyrimidine-containing compound catabolic process
neuron death
pyrimidine-containing compound metabolic process
neuron projection guidance
heterocycle catabolic process
cellular nitrogen compound catabolic process
neuron projection morphogenesis
organic cyclic compound catabolic process
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
nucleobase-containing small molecule metabolic process
chemotaxis
taxis
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
neuron differentiation
organonitrogen compound catabolic process
cell death
plasma membrane bounded cell projection organization
cell projection organization
locomotion
generation of neurons
movement of cell or subcellular component
neurogenesis
cell development
small molecule metabolic process
organic substance catabolic process
cellular catabolic process