DSC2 [The Human Chemical-Genetic Interaction Map Project]

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======= DSC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSC2
  * **<color #00a2e8>Official Name</color>**: desmocollin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1824|1824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02487|Q02487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125645|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin pro|
|Cadherin C|
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|
|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|
|cardiac muscle cell-cardiac muscle cell adhesion|
|bundle of His cell to Purkinje myocyte communication|
|regulation of ventricular cardiac muscle cell action potential|
|desmosome|
|regulation of cardiac muscle cell action potential|
|heterotypic cell-cell adhesion|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|cell communication involved in cardiac conduction|
|intercalated disc|
|regulation of action potential|
|homotypic cell-cell adhesion|
|cornified envelope|
|regulation of cardiac muscle contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of heart rate|
|cell-cell adherens junction|
|cornification|
|multicellular organismal signaling|
|cellular response to starvation|
|regulation of muscle contraction|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell-cell junction|
|response to starvation|
|keratinization|
|cellular response to nutrient levels|
|regulation of muscle system process|
|regulation of heart contraction|
|cytoplasmic vesicle|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cellular response to extracellular stimulus|
|keratinocyte differentiation|
|regulation of blood circulation|
|epidermal cell differentiation|
|cellular response to external stimulus|
|skin development|
|regulation of actin filament-based process|
|epidermis development|
|regulation of membrane potential|
|response to nutrient levels|
|cell-cell adhesion|
|response to extracellular stimulus|
|regulation of system process|
|epithelial cell differentiation|
|calcium ion binding|
|cell adhesion|
|biological adhesion|
|regulation of cellular component movement|
|programmed cell death|
|cell death|
|epithelium development|
|cellular response to stress|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.94|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.85|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.77|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12898
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSC2 Expression in NALM6 Cells: 2.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>