DSC2

Entrez Summary: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell to Purkinje myocyte communication
regulation of ventricular cardiac muscle cell action potential
desmosome
regulation of cardiac muscle cell action potential
heterotypic cell-cell adhesion
regulation of heart rate by cardiac conduction
regulation of cardiac muscle cell contraction
regulation of actin filament-based movement
cell communication involved in cardiac conduction
intercalated disc
regulation of action potential
homotypic cell-cell adhesion
cornified envelope
regulation of cardiac muscle contraction
regulation of striated muscle contraction
cardiac conduction
regulation of heart rate
cell-cell adherens junction
cornification
multicellular organismal signaling
cellular response to starvation
regulation of muscle contraction
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
response to starvation
keratinization
cellular response to nutrient levels
regulation of muscle system process
regulation of heart contraction
cytoplasmic vesicle
cell-cell adhesion via plasma-membrane adhesion molecules
cellular response to extracellular stimulus
keratinocyte differentiation
regulation of blood circulation
epidermal cell differentiation
cellular response to external stimulus
skin development