DSCC1 [The Human Chemical-Genetic Interaction Map Project]

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======= DSCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DSCC1
  * **<color #00a2e8>Official Name</color>**: DNA replication and sister chromatid cohesion 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79075|79075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVC3|Q9BVC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DSCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DSCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:19907496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2036|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-translational protein acetylation|
|maintenance of sister chromatid cohesion|
|maintenance of mitotic sister chromatid cohesion|
|regulation of DNA-directed DNA polymerase activity|
|positive regulation of DNA-directed DNA polymerase activity|
|Ctf18 RFC-like complex|
|DNA clamp loader activity|
|mitotic sister chromatid cohesion|
|single-stranded DNA helicase activity|
|sister chromatid cohesion|
|chromosome, centromeric region|
|regulation of DNA-dependent DNA replication|
|positive regulation of DNA biosynthetic process|
|mitotic sister chromatid segregation|
|regulation of DNA replication|
|DNA duplex unwinding|
|regulation of DNA biosynthetic process|
|chromatin|
|DNA geometric change|
|sister chromatid segregation|
|protein acetylation|
|mitotic nuclear division|
|protein acylation|
|positive regulation of DNA metabolic process|
|DNA replication|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|regulation of DNA metabolic process|
|post-translational protein modification|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of transferase activity|
|cell cycle process|
|chromosome organization|
|cell cycle|
|positive regulation of catalytic activity|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.17|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.14|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.13|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.96|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.88|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.75|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.86|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.9|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chtf8|CHTF8]]|0.705|
|[[:human genes:c:chtf18|CHTF18]]|0.564|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|3/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1683
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DSCC1 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>