DSCC1

Entrez Summary: N/A
UniProt Summary: Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:19907496}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	1/1
gastric	0/16
kidney	3/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
CHTF8	0.705
CHTF18	0.564

post-translational protein acetylation
maintenance of sister chromatid cohesion
maintenance of mitotic sister chromatid cohesion
regulation of DNA-directed DNA polymerase activity
positive regulation of DNA-directed DNA polymerase activity
Ctf18 RFC-like complex
DNA clamp loader activity
mitotic sister chromatid cohesion
single-stranded DNA helicase activity
sister chromatid cohesion
chromosome, centromeric region
regulation of DNA-dependent DNA replication
positive regulation of DNA biosynthetic process
mitotic sister chromatid segregation
regulation of DNA replication
DNA duplex unwinding
regulation of DNA biosynthetic process
chromatin
DNA geometric change
sister chromatid segregation
protein acetylation
mitotic nuclear division
protein acylation
positive regulation of DNA metabolic process
DNA replication
nuclear chromosome segregation
chromosome segregation
nuclear division
DNA conformation change
organelle fission
regulation of DNA metabolic process
post-translational protein modification
mitotic cell cycle process
positive regulation of transferase activity
mitotic cell cycle
regulation of transferase activity
cell cycle process
chromosome organization
cell cycle
positive regulation of catalytic activity