CHTF18

Entrez Summary: N/A
UniProt Summary: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 16/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	1/1
gastric	1/16
kidney	2/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MLN-4924 0.2μM R00 exp21	-1.83
CAY10603 0.55μM R08 exp467	1.79

Gene	Correlation
DSCC1	0.564
CHTF8	0.564

regulation of DNA-directed DNA polymerase activity
positive regulation of DNA-directed DNA polymerase activity
Ctf18 RFC-like complex
DNA clamp loader activity
single-stranded DNA helicase activity
regulation of DNA-dependent DNA replication
positive regulation of DNA biosynthetic process
regulation of DNA replication
DNA duplex unwinding
regulation of DNA biosynthetic process
DNA geometric change
positive regulation of DNA metabolic process
DNA replication
DNA conformation change
regulation of DNA metabolic process
positive regulation of transferase activity
regulation of transferase activity
chromosome organization
cell cycle
positive regulation of catalytic activity
ATP binding
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
membrane
positive regulation of biosynthetic process